Tailor Made Solutions
Ta
Tailor
Custom ingredients to make you succeed
Expertise & technologies
Screening
- Data mining, microorganisms, metabolites, peptides, proteins, enzymes
Synthetic biology
- Genetic & metabolic engineering
- Expression strains engineering(microalgae, yeast, bacteria, plant stem cells)
Biocatalytic processes
- Reaction optimization (DoE)
- Industrial conditions screening
Directed evolution
- Enzyme improvement
- Smart libraries design
- EvosightTM evolution
- L-ShufflingTM evolution
Fermentation
- Bioreactors (Lab-scale to 300L)
- Photobioreactors
- Process optimization
DSP
- Liquid/Solid separation
- Microfiltration, ultrafiltration, diafiltration
Analytical
- HPLC- MSMS, NMR, solid state studies, scanning electronic microscopy
Computational
- Private genomes database
- Unique annotation & genes searching tools
- Proteins 3D modeling
- Molecular dynamics
- Protein/substrate docking…
Our expertise
Proof of concept
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- Identification and design of first hits
(microorganisms, enzymes, proteins,
metabolites…) - Demonstration of biocatalytic or biological
transformation
Pilot scale
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- Process book
- Strain, protein/peptide/enzyme productions
- Biocatalytic assay scale-up
- Advanced Analytical characterization
- Control Quality stability & release
Industrial production
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- From biological material to biocatalytic process
through worldwide Seqens facilities
Green chemistry: innovative solutions for lower environmental footprint and naturalness
Biocatalysis_Natural chemistry from Biodiversity
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- Possibly aqueous and ambient temperature conditions
- No metal or less metal, enzymes are biodegradable catalysts
Enzymes form a structure with a selective catalytic site (active site). Screening biodiversity allows to find targeted substrate specificity. Improve naturalness of manufacturing processes.
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Naturalness
- Fragrances & Flavors: Development of fully enzymatic pathways for EU natural label
- Cosmetics: Development of COSMOS certified processes from native enzyme sequences
Multipurpose flow chemistry
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- Lower usage of solvents
- Lower energy requirement
- Safer when compared to same
reaction in batch mode
Significant reduction of environmental footprint compared to multipurpose batch
- ~30% energy consumption reduction
- From 50% to 80% reduction of solvent consumption
- ~50% reduction of environmental footprint
Greener synthesis pathways
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- Proposal of alternative synthetic routes associated with lower environmental footprint
- Choice of solvents (safer, biobased or circular)
Example of the new industrial process developed by SEQENS for Paracetamol manufacturing
in France
- ~90% reduction of CO2 eq emissions
- ~90% Reduction of waste discharge
- From 80% to 90% reduction of environmental footprint